[grandmatParticipant]

Anyone been on a clinical trial my husband has been and still is on one for myeloma after 2 years continuous chemo have you or did you get a break from chemo .

[rabbitParticipant]

Hi Grandmat, welcome to this forum.

Could you please more information about the clinical trial that your husband has been on? Many of us are interested in possible future treatments.

A lot of us MM patients, whether or not on a clinical trial, don’t have a break as even if/when in remission, we may be on maintenance chemotherapy. This may mean lower and/or less frequent doses, but it helps to delay the MM from coming back.

Regards
Rabbit

[grandmatParticipant]

Hi rabbit my husband is on the fitness trial , he’s been on chemo for the first year bu5 now in the second year he takes less medication but is taking either a placebo or a new added tablet but we don’t know obviously , he’s in his 2nd cycle of this 2 nd year , he has had some sickness side effects which he didn’t have before. He does have other side effects but he’s had those very early on in the first year , my husband is 78 in August so unable to have STC.He does suffer quite badly with peripheral neuropathy struggles to walk far now ,hope this helps .

• This reply was modified 4 months, 4 weeks ago by  grandmat.

[rabbitParticipant]

Hi Grandmat,

I did a bit of reading up on the Fitness trial from here: https://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-trial-of-ixazomib-lenalidomide-and-dexamethasone-for-people-with-myeloma-fitness#undefined

It seems from your message that your husband is on the maintenance phase, but I don’t see anything about a new added tablet (unless the ixazomib that he was lreviously taking is now in a new format in the maintenance. This has left me a bit confused, but I am only an MM layperson.

Regards
James

[grandmatParticipant]

Hello James I’m sorry I didn’t explain it very well, my husband has been taking Lenalidonide, Ixazomib and Dexamethasone now in the 2nd part of the trial Dexanethasone has been ceased ,Ixazomib we don’t know now whether he’s receiving that or it’s a placebo Lenalidomibe he’s still taking hope that’s more understandable

[rabbitParticipant]

Hi Grandmat,

Thank you for explaining.

Lenalidomide is pretty standard maintenance chemotherapy now, and I think I am right in saying that it is the best in that role currently (or as researchers would put it, it is the ‘standard of care’), unless there is a specific reason otherwise for that patient. I am on it myself.

In terms of the trial, whether or not your husband is getting Ixazomib, my best guess is that he will be kept on the current maintenance until/unless either the side effects get too serious to continue with, or remission ends.

Regards
Rabbit

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