[mf1Participant]

Hi all, I am a carer of my husband who had MM since 2012-2013. He is being sent for bi-specific antibody treatment next week. We know he will be in the hospital for 2 weeks. We know that he may have some gastro intestinal side effects. PLEASE COULD YOU SHARE WHAT SIDE EFFECTS you had during the treatment and how quick was your recovery after the treatment. How soon would he be able to return to work? [I know it is different for every Patient but would appreciate your insights]

• This topic was modified 1 month, 2 weeks ago by  mf1.

[rabbitParticipant]

Hi mf1,
I don’t personally have experience of bispecific antibodies, but there have been many posts on patients’ experiences of Elranatamab (which is a bispecific antbody).

See: https://forum.myeloma.org.uk/forums/topic/elranatamab/

Regards
Rabbit

[rabbitParticipant]

Hi mf1,

I should provide a bit more detail.

There are currently two bispecific antibody treatments which have been approved in the UK: Elranatamab and Teclistamab. They are similar in that they both target part of a myeloma cell called BCMA. Therefore the side effects are broadly similar.

A third bispecific antibody may be approved soon, called Talquetamab. This targets a completely different part of a myeloma cell called GPRC5D. The side effects are therefore pretty different.

Other bispecific antibody treatments are in development. You haven’t provided detail, so for all I know your husband may be going into a clinical trial for one of these.

[lafleckParticipant]

Hi. My husband will very likely be starting Elranatamab as his 4th line treatment in the coming months. I would be very interested in how your husband’s treatment goes. Wishing you both the best.

[pennylawsonParticipant]

Hi. I started on Elranatamab last October (also posting on Elranatamab thread) as 4th line treatment, then changed to Teclistamab in February due to skin rash from Elranatamab. Teclistamab is working 100% at keeping my free light chain count below detectable and there are very few side effects for me, so I’m delighted with it. I do get bouts of diarrhoea which I can keep under control with Loperamide, and also now and again I get nasty headaches which last 24 – 48 hrs. Otherwise all good. I’ve also been told that as I’ve been on BITE for nearly a year now I will be able to go down from 2 weekly injections to 4 weekly, which apparently is just as effective. Happy to answer any specific questions you have if I can help. Penny

[mf1Participant]

Thank you so much everybody! That was great help! UPDATE: Husband is doing well. The team at the Hospital and his Consultants are amazing! I am so grateful to these people! He reacted quite badly to the first injection of Talquetamab. It was strange… he was carefully observed and I was in the room with him, but he suddenly started shaking, temperature risen but he felt cold and I can see colour draining from his fingers. He also got confused. This lasted 20 min max with the team at the hospital sorting him out. Since then he had 2 other treatments and is back home. This is NOTHING like the treatments he had 12 years ago. To me, it is amazing. I am testing his ‘marbles’ with extensive house DIY tasks at the moment (hoping he will have enough of this and go back to work 🙂 soon).

• This reply was modified 3 weeks, 4 days ago by  mf1.

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