[unlclemomoParticipant]

I was originally diagnosed with PSC while living in London and have since had my liver tx in Canada. I lived in the UK from 1986-2000 & 2007-2010. I likely had PSC progressing from about 1983-onward, along with colitis (which was treated – total colectomy – in 1998, and I have an ileo-anal pouch).

I had my liver tx during 2000, and was followed at the Royal Scottish Liver Transplant unit during my 2007-2010 time in the UK.

I have since been diagnosed (Aug 2014) with multiple myeloma and the possible plan is an autologous stem cell transplant.

Has anyone had any similar experience or aware of any experience of a liver tx recipient receiving an stem cell transplant for similar treatment? Is this better asked in a different part of the forum?

Of experience of liver invovlement/recovery post high-dose chemo (melphalan)

Any thoughts or help would be appreciated, though we are finding out this is something relatively new for us!

Bye for now, thanks…

C.

[ellenModerator]

I am sorry that you have not yet received  any replies to your post. I suspect that as your situation is quite a complicated one, that no one on the forum has similar experiences to share.
My name is Ellen and I am one of the Myeloma Information Specialists at Myeloma UK; perhaps I can clarify some things for you. Liver function is monitored very closely in myeloma patients as many of the drugs used and in some cases the myeloma itself, can affect the liver, so every time you have blood taken your liver function will be monitored. If it looks as if your liver function is being affected then your haematologist may lower the dose of the drug which may be causing it, or even stop it temporarily (until liver function recovers), or stop the drug permanently if necessary.
High-dose chemotherapy, in particular, can be toxic to the liver and the decision to go ahead with a stem cell transplant would be very carefully considered. Some haematologists may consider using a lower dose of the chemotherapy drug used – usually melphalan. Your haematologist will be able to clarify these things for you.
I hope this has been of some help, but if you have any further questions, or would like to talk things through, please feel free to call the Myeloma Infoline if you are in the UK on 0800 980 3332 – I or one of my colleagues can clarify things for you further. Alternatively you can email directly to askthenurse@myeloma.org.uk

With best wishes

Ellen

[Author]

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