I've just completed my first three week cycle of revlimid/dex, and I have felt significantly more fatigued than with my previous two treatments (CDT and then Velcade/Dex). The tiredness has been accompanied with difficulty sleeping (despite concurrent treatment with Fentanyl/Pregabalin/Amitriptiline for PN caused by Velcade). I'm optimistic, and hoping things will improve as my body becomes accustomed to the new regime. Best wishes to fellow sufferers, may you all find happiness.