Hi Morwenna,
Hope you are well other than the obvious.
I was on Questran for just over 9 months, varying dosages. 1 a day, 1 every other day, half a sache daily but made no difference. I am now prescribed a tablet version which I can remember the name of at the moment but although it hasn’t stopped I am more in control. I’ve only been on these a few weeks so hopefully they’ll make a difference. I’ve stopped caffeine this past week and carbonated drinks. Although I only had a bottle of lucozade on a morning to kick start me as like you the fatigue does kick in.