[oscar100Participant]

Hi, I will be starting a second line of treatment shortly having started to relapse. I was diagnosed in September 2014 and initially treated with VTd and then had a transplant in May 2015. I would be grateful if anyone could share their experiences with KRd, DVd or second transplant. My consultant seems to be favouring KRd but no decision has yet been made.TIA

[mulberryParticipant]

Congratulations on achieving a 9 year remission, & hopefully you’ll be back in remission shortly.

I relapsed this time last year 4 years after SCT. I was advised to have DVd which I did, and remain on Daratumumab maintenance every 4 weeks.
Although I had side effects (neuropathy) on full dose Velcade, as I had had during induction treatment, on half dose this lessened and then cleared after the Velcade element finished. I had startling side effects after the first two doses of Daratumumab, which is not unusual, but after this, no side effects from Dara at all. For me it’s been the most benign myeloma drug I’ve experienced. DVd was much easier to endure than induction VRd. For the past few months I’ve just been on one Dara injection (& low dose steroids) once every 4 weeks. I’m finding this very easy maintenance, easier than lenalidomide maintenance was.
I was not particularly averse to having another SCT, but DVd has been much easier.

[oscar100Participant]

Thanks very much for such a useful and succinct response.

[rabbitParticipant]

Hi,

I know that this response does not answer your request, but it still seems relevant. I am geeky – although I also want to ‘know my enemy’. Anyway, the link below compares the effectiveness of KRd compared to DVd (albeit in newly diagnosed cases):

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368661/

In summary, with KRd, the myeloma did not return for a significantly longer time than with DVd (‘significant’ in both the day to day and the statistical meanings).

You may or may not want to mention it to your doctor.

By the way, you phrased your options as DVd or KRd or transplant as though only one of these were possible. Couldn’t you have DVd or KRd as induction therapy before a transplant?

Regards
Rabbit

[oscar100Participant]

Hi Rabbit, thanks for your response. My question concerned my second line as I’ve already had an SCT.

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