Yes, an increase in light chains can still be significant even if the ratio is normal. Light chains are proteins produced by plasma cells, and their levels can indicate various health conditions. A normal ratio suggests a balanced production, but elevated light chain levels might still signal underlying issues such as kidney dysfunction, infections, or early stages of plasma cell disorders like multiple myeloma. It’s crucial to consider the absolute levels and clinical context rather than relying solely on the ratio. Consulting a healthcare professional for a comprehensive evaluation is essential to understand the implications of increased light chains.
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