Possible new treatment for myeloma

This topic contains 15 replies, has 11 voices, and was last updated by  mhnevill 11 years, 2 months ago.

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  • #95944

    Mothas
    Participant

    Canadian researchers appear to have made a breakthrough in blood cancer treatments leading to a possible cure. They talk largely about leukaemia but also myeloma, human phase 1 and 2 trials possibly to start in 12 – 24 months. The treatment involves virus derived particles that can target the cancer.

    "Doctors at the Ottawa Research Institute call it a major finding in the battle against the blood cancer leukemia."

    Video here:
    http://www.ctvnews.ca/video?playlistId=1.1409054

    Press release here
    http://www.ohri.ca/newsroom/newsstory.asp?ID=355

    #95945

    jmsmyth
    Participant

    Tom thank you for posting this amazing research. It's very exciting and promising. Give you a feel good factor

    How are things with you? Hope you are I proving every day,

    Love Jean x

    #95948

    Michele
    Participant

    Very interesting Tom.

    Only a matter of time before the big breakthrough.

    #95949

    san
    Participant

    Thanks for the link Tom 🙂 San x

    #95950

    mhnevill
    Participant

    Hi Tom

    I have been pinning my hopes on the American "Black Swan" Project which is searching for a cure. This Canadian news is great.

    We just all need to hang in there!

    Best wishes to you.

    Mavis

    #95951

    dickb
    Participant

    I understand that there is a small Isreali company researching along the same lines,my wife is fantastic at research on the internet. If true, then there is more hope that someone will achieve a breakthrough

    #95946

    Mothas
    Participant

    Jean I'm good, I'm about 3 weeks out of hospital now and feeling better every day. I generally manage a 30 minute walk during the day and am pottering about the house the rest of the time. My diet is getting more varied too 🙂

    #95947

    jmsmyth
    Participant

    Tom that's great. Frank has tried walking but can't go very far as he has terrible back pain – apparently nothing to do with MM but an old injury he got playing rugby.

    Every day it gets a little better. Take care
    Love Jean x

    #95952

    bandityoga
    Participant

    Hi Tom

    Just read the report and it is great news. Hopefully they will find a cure soon.

    Nice to know you are doing well.

    Maureen

    #95953

    DaiCro
    Participant

    These reports from individual hospitals and research labs are very interesting but they don't seem to get much support from the major players such as the Pharmaceutical Companies and larger Myeloma councils etc. 🙁

    I really do hope that one of these smaller research labs comes up trumps but for the moment I am keeping my eye on the major researches… and hope that they can improve their lab success to patients hands in much quicker time.8-)

    Dai.

    #95956

    Perkymite
    Participant

    Thanks Tom, That is more than good news. Trials in 1 to 2 years I wonder if other labs will take it up world wide?

    kindest regards – vasbyte

    David

    #95954

    Mothas
    Participant

    It's these university and hospital based labs that will come up with the cure IMHO.

    The big pharma companies are good at further finessing existing treatments but they have less motivation to risk their profits developing novel approaches which is what publicly funded labs can do.

    I'm sure Calgary already have commercial partners that they work with and if the initial trials look good will be fighting them off.

    #95955

    sessakelly
    Participant

    Sounds strange I know but your video news made me both really hopeful and anxious at the same time. I didn't know much about vaccine therapy before, now I cant help but hope that there's at least a real chance of a cure imminently.
    But what re the chances of any proposed trials here do you think?
    Thank you Tom for giving me a glimmer of hope. Thank you.

    #95957

    Mothas
    Participant

    There's another video report if you follow the link at the bottom of this post

    [b]Ottawa researchers hopeful nano-particles can cure leukemia[/b]

    Ottawa researchers are cautiously using the word "cure" when talking about new research into leukemia. The research is new and a long way from helping human patients, but in mice, they’ve developed tiny particles that, in the lab, cause cancerous white blood cells to kill themselves.

    For patients with acute myeloid leukemia, stem cell transplants and heavy chemotherapy have been the only hope for a cure. But even at that, the survival rate is among the worst of all the cancers at 22%. What's happening inside a lab at the Ottawa Hospital Research Institute is giving new hope, though, for a cure for even the toughest types of leukemia. Doctors David Conrad and John Bell have developed a tiny nano-particle that causes human blood cancer cells to kill themselves. The results on mice have been dramatic.

    “In 60 percent of the mice, we had a cure,” explains Dr. David Conrad, a hematologist conducting research in the Blood and Marrow Transplant Program at the Ottawa Hospital, “so in other words, if we left these mice to continue living in the lab, they would live out their normal lifespan and were essentially cured of the leukemia. All the other untreated mice died within 21 days.”

    The particles were able to kill multiple forms of leukemia in the lab including samples taken from local patients who had failed all other forms of therapy. It hasn't yet been tried on humans and likely won't for a couple more years.

    Dr. Conrad has captured on video what happens to the leukemia cells when they're exposed to the killer nano-particles. At first, he says, the cells are happy and moving. Once the agent is introduced, very rapidly they change behavior.

    “They become bloated and they shrivel up and you see all there's no movement and you see all the cancer cells in the plate completely dead.”

    “They think this agent is Def Con 5 and they undergo suicide,” says Dr. Conrad.
    For biomedical science student Mina Rizk, working alongside the researchers in a potential cure for leukemia is a once in a lifetime opportunity.

    "I’m grateful to have found this opportunity,” says Rizk, “I'm very aware that not many students have the chance I do. While their focus has been blood cancers, the researchers say they've had some success on solid cancer tumors, too. the next step, though, are clinical trials to see if they can kill the cancer cells in humans the same way they did in mice

    Read more: http://ottawa.ctvnews.ca/ottawa-researchers-hopeful-nano-particles-can-cure-leukemia-1.1409330#ixzz2dB42HXIL

    #95958

    daisychain
    Participant

    Thanks Tom

    Dawn xxx

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