Hi millie12
I can’t give you first hand experience but lots of people using myeloma Facebook groups seem to be doing very well with daratumumab, velcade and dex as a second line treatment. I’d personally not want to miss out the opportunity to have daratumumab at some stage. It is a monoclonal antibody which attaches to a specific protein on the surface of myeloma cells enabling your immune system to recognise the cell as myeloma and to get rid of it. This is a different mechanism to the drugs you (& I ) had before. I’d check out if you don’t have it as second line whether you will miss out altogether. Lenalidomide on the other hand, seems to be given at a variety of different stages, so if you can keep one of the drugs back for use later that would come into my decision making. The biggest side effect problem with DVD seems to be the potential for a severe reaction during or after the first infusion which is why it is done in hospital. Like every myeloma drug, there are potential serious side effects with DVD, but some people appear to be living very well with it, and their myeloma levels quickly responded to the treatment.
