Hi Lynne what an awful time for you both no wonder you are frightened but dont give up hope It sounds as if they are beginning to get things under control, Dex is an amazing drig and very useful in myeloma as it reduces inflamation and helps other drugs to work There are a couple of people who post who have had acute kidney problems and needed dialysis but they werent on it forever , I am sure they will reply to your post and give you more reassurance than I can Four years ago I was in a bad way too , I had lost 3 vertebrae to myeloma and had major back surgery to prevent paralysis, my back is now mainly metal rods and plates …metal mickey!!The percentage of myeloma in my system was over 90% within a few months of starting treament this had lowered to a point where I could have a stem cell transplant After my transplant I was told the paraproteins were too low to quantify , meaning a partial remission which lasted 18 months I wont deny the treatment was tough but life got back to a normal state , maybe different but good all the same S please dont despair things will get easier and dont forget we are all here to support you both Sciatica is an awful pain so please try and make sure you take it easy or your husband will be worrying about you as well and dont feel guilty Have you got close friends or family who can help at all ? If you have ont be shy or too proud to ask them to help , they will be only too glad I am sure My best wishes to you both and hang in there good times arent far away Bridget